Référentiel des médicaments
Mecasermin
Mecasermin is a medicine in the class endocrine. It is used for growth failure.
- Classe médicamenteuse: Endocrine
- Indications: growth failure
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Endocrine
- Code ATC
- H01AC03
- Formes courantes
- injection
- Dosages courants
- 10 mg/ml, 40 mg, 40 mg/4 ml
- Interactions connues
- 46 (Majeure: 6 · Modérée: 37 · Mineure: 3)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Recombinant human IGF-1 used as replacement therapy in patients primary severe IGF-I deficiency, growth hormone receptors in the liver that are unresponsive to GH
Posologie adulte habituelle (résumé de la notice)
Not indicated for adult use
Grossesse et allaitement
- Grossesse
- Unknown Used in children with IGF-1 deficiency; exposure in pregnancy is unlikely as it is not used after growth plates close. No human data; no birth defects in rats or rabbits, but fetal deaths in rabbits above the human dose. Use only if clearly needed.
- Allaitement
- Unknown No data on passage into milk or effects on the infant. It is a protein, so little would be absorbed by the infant; it contains benzyl alcohol. US label: weigh breastfeeding benefits against the mother's need.
Effets indésirables signalés
- Dizziness
- Convulsion
- Hypoglycemia
- Tonsillar hypertrophy
- Cardiac murmur
Précautions particulières
- Allergic reactions reported include localized (injection site) reactions to severe systemic reactions, including anaphylaxis requiring hospitalization
- Symptoms associated with intracranial hypertension including nausea, headache, papilledema, vomiting, visual changes reported; funduscopic examinations are recommended
- Lymphoid hypertrophy that may lead to complications such as chronic middle ear effusions, snoring, and sleep apnea reported
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (46)
- Gliclazide + Mecasermin Major
- Glyburide-metformin + Mecasermin Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-liraglutide + Mecasermin Major
- Insulin glargine-lixisenatide + Mecasermin Major
- Insulin neutral human + Mecasermin Major
- Acarbose + Mecasermin Moderate
- Alogliptin-metformin + Mecasermin Moderate
- Alogliptin-pioglitazone + Mecasermin Moderate
- Canagliflozin-metformin + Mecasermin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Mecasermin used for?
Mecasermin is a medicine in the class endocrine. It is used for Growth failure.
What side effects have been reported with Mecasermin?
Dizziness, Convulsion, Hypoglycemia, Tonsillar hypertrophy, Cardiac murmur.
Can Mecasermin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Used in children with IGF-1 deficiency; exposure in pregnancy is unlikely as it is not used after growth plates close. No human data; no birth defects in rats or rabbits, but fetal deaths in rabbits above the human dose. Use only if clearly needed. Breastfeeding: Unknown. No data on passage into milk or effects on the infant. It is a protein, so little would be absorbed by the infant; it contains benzyl alcohol. US label: weigh breastfeeding benefits against the mother's need.
What does Mecasermin interact with?
MediHelp lists 46 known interactions for Mecasermin. Major: 6 · Moderate: 37 · Minor: 3. The most serious include Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart.
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