Interactions médicamenteuses
Alogliptin-pioglitazone + Mecasermin
Gravité: Modérée
Alogliptin-pioglitazone and Mecasermin: moderate interaction.
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Résumé
Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering effects. Added to antidiabetic drugs it can increase the risk of hypoglycemia. Mecasermin must be given with food for this reason.
Ce que signifie cette interaction, en termes simples
Alogliptin-pioglitazone and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Mecasermin belongs to Endocrine.
Pourquoi elle survient
Additive pharmacodynamic glucose-lowering through insulin-like activity of IGF-1.
Conduite à tenir
Monitor blood glucose closely when starting mecasermin and consider lowering antidiabetic doses. Give mecasermin with or shortly after a meal and educate the patient on hypoglycemia symptoms.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Alogliptin-pioglitazone
Autres interactions de Mecasermin
Questions fréquentes
Can I take Alogliptin-pioglitazone with Mecasermin?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering effects. Added to antidiabetic drugs it can increase the risk of hypoglycemia. Mecasermin must be given with food for this reason.
How serious is the interaction between Alogliptin-pioglitazone and Mecasermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting mecasermin and consider lowering antidiabetic doses. Give mecasermin with or shortly after a meal and educate the patient on hypoglycemia symptoms.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
