Interactions médicamenteuses
Insulin degludec-insulin aspart + Mecasermin
Gravité: Majeure
Insulin degludec-insulin aspart and Mecasermin: major interaction.
Dernière mise à jour
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Résumé
Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity, so combining it with insulin can cause additive and sometimes severe hypoglycemia.
Ce que signifie cette interaction, en termes simples
Insulin degludec-insulin aspart and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-insulin aspart belongs to Endocrine; Mecasermin belongs to Endocrine.
Pourquoi elle survient
Additive pharmacodynamic effect: IGF-1 acts on insulin receptors and IGF-1 receptors to lower blood glucose.
Conduite à tenir
Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce the insulin dose as needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Majeure
- Clozapine + Insulin degludec-insulin aspart Majeure
- Diazoxide + Insulin degludec-insulin aspart Majeure
- Ethanol + Insulin degludec-insulin aspart Majeure
- Insulin degludec-insulin aspart + Pioglitazone Majeure
- Insulin degludec-insulin aspart + Pramlintide Majeure
Autres interactions de Mecasermin
Questions fréquentes
Can I take Insulin degludec-insulin aspart with Mecasermin?
MediHelp rates the interaction as major. Insulin degludec-insulin aspart and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity, so combining it with insulin can cause additive and sometimes severe hypoglycemia.
How serious is the interaction between Insulin degludec-insulin aspart and Mecasermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce the insulin dose as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
