Interactions médicamenteuses
Insulin degludec-liraglutide + Mecasermin
Gravité: Majeure
Insulin degludec-liraglutide and Mecasermin: major interaction.
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Résumé
Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity. Combined with insulin and liraglutide it can cause additive and sometimes severe hypoglycemia.
Ce que signifie cette interaction, en termes simples
Insulin degludec-liraglutide and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-liraglutide belongs to Endocrine; Mecasermin belongs to Endocrine.
Pourquoi elle survient
IGF-1 receptor activation produces insulin-like glucose uptake, adding to insulin and GLP-1 effects.
Conduite à tenir
Monitor glucose frequently and give mecasermin with or shortly after a meal; reduce the insulin dose if hypoglycemia occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Insulin degludec-liraglutide
Autres interactions de Mecasermin
Questions fréquentes
Can I take Insulin degludec-liraglutide with Mecasermin?
MediHelp rates the interaction as major. Insulin degludec-liraglutide and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity. Combined with insulin and liraglutide it can cause additive and sometimes severe hypoglycemia.
How serious is the interaction between Insulin degludec-liraglutide and Mecasermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently and give mecasermin with or shortly after a meal; reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
