Référentiel des médicaments
Methyldopa
Methyldopa is a medicine in the class cardiovascular. It is used for hypertension.
- Classe médicamenteuse: Cardiovascular
- Indications: hypertension
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Formes courantes
- comprimé
- Dosages courants
- 250 mg, 500 mg
- Interactions connues
- 92 (Contre-indiquée: 1 · Majeure: 5 · Modérée: 82 · Mineure: 4)
- Noms commerciaux
- 15
- Pays et marchés
- 4
Indications
Mécanisme d'action
Methyldopa may lower blood pressure by stimulating central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity.
Posologie adulte habituelle (résumé de la notice)
Hypertension (Initial): 250 mg PO q8-12hr for 2 days, increase q2Days PRN
Grossesse et allaitement
- Grossesse
- Safe Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine.
- Allaitement
- Safe Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
Effets indésirables signalés
- Dizziness
- Bradycardia
- Angina
- Orthostatic hypotension
- Depression
- Lethargy
Contre-indications
- Active liver disease, liver disorders associated with previous methyldopa treatment
- Hypersensitivity to methyldopa or other ingredients (eg, sulfites)
- Pheochromocytoma
Précautions particulières
- May impair ability to perform hazardous tasks
- Interferes with some lab tests
- IM/SC NOT recommended due to erratic absorption
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (92)
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
- Adrenaline-articaine + Methyldopa Moderate
- Apomorphine + Methyldopa Moderate
- Aripiprazole + Methyldopa Moderate
- Benperidol + Methyldopa Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Methyldopa used for?
Methyldopa is a medicine in the class cardiovascular. It is used for Hypertension.
What side effects have been reported with Methyldopa?
Dizziness, Bradycardia, Angina, Orthostatic hypotension, Depression, Lethargy.
Can Methyldopa be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine. Breastfeeding: Safe. Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
What does Methyldopa interact with?
MediHelp lists 92 known interactions for Methyldopa. Contraindicated: 1 · Major: 5 · Moderate: 82 · Minor: 4. The most serious include Tranylcypromine, Iobenguane i, Lofexidine.
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