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Interactions médicamenteuses

Apomorphine + Methyldopa

Gravité: Modérée

Apomorphine and Methyldopa: moderate interaction.

Dernière mise à jour

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Résumé

Both apomorphine and methyldopa can cause hypotension, and apomorphine is notable for orthostatic hypotension and syncope. Combined use may worsen low blood pressure and dizziness, particularly during apomorphine initiation.

Ce que signifie cette interaction, en termes simples

Apomorphine and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Apomorphine belongs to Central Nervous System; Methyldopa belongs to Cardiovascular.

Niveau de preuve: Low

Pourquoi elle survient

Additive hypotensive effects of dopamine agonism and methyldopa's central alpha-2 mediated sympathetic inhibition.

Conduite à tenir

Monitor supine and standing blood pressure when starting apomorphine and consider reducing antihypertensive doses if hypotension occurs.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apomorphine with Methyldopa?

MediHelp rates the interaction as moderate. Apomorphine and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both apomorphine and methyldopa can cause hypotension, and apomorphine is notable for orthostatic hypotension and syncope. Combined use may worsen low blood pressure and dizziness, particularly during apomorphine initiation.

How serious is the interaction between Apomorphine and Methyldopa?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting apomorphine and consider reducing antihypertensive doses if hypotension occurs.

What other medicines interact with Methyldopa?

MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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