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Interactions médicamenteuses

Methyldopa + Tranylcypromine

Gravité: Contre-indiquée

Methyldopa and Tranylcypromine: contraindicated interaction.

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Résumé

MAO inhibitors are listed as contraindicated with methyldopa in labeling because of the risk of hypertensive reactions and excitation, and tranylcypromine may also oppose the hypotensive effect. Methyldopa is metabolised to catecholamine-like compounds that can be potentiated when MAO is inhibited.

Ce que signifie cette interaction, en termes simples

Methyldopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Methyldopa belongs to Cardiovascular; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition prevents breakdown of methyldopa-derived catecholamine metabolites, causing excess adrenergic stimulation.

Conduite à tenir

Do not combine. Allow an adequate washout, about 14 days after stopping the MAOI, before starting methyldopa, and choose another antihypertensive.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Methyldopa with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Methyldopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors are listed as contraindicated with methyldopa in labeling because of the risk of hypertensive reactions and excitation, and tranylcypromine may also oppose the hypotensive effect. Methyldopa is metabolised to catecholamine-like compounds that can be potentiated when MAO is inhibited.

How serious is the interaction between Methyldopa and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow an adequate washout, about 14 days after stopping the MAOI, before starting methyldopa, and choose another antihypertensive.

What other medicines interact with Methyldopa?

MediHelp also lists interactions of Methyldopa with, for example, Iobenguane i, Lofexidine, Pexidartinib. The full list is on the Methyldopa page.

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