Interactions médicamenteuses
Iobenguane i + Methyldopa
Gravité: Majeure
Iobenguane i and Methyldopa: major interaction.
Dernière mise à jour
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Résumé
Methyldopa interferes with catecholamine handling and may reduce uptake of iobenguane into target cells. This can lower its diagnostic or therapeutic efficacy.
Ce que signifie cette interaction, en termes simples
Iobenguane i and Methyldopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Depletion or false-transmitter replacement of catecholamine stores and altered neuronal uptake reduce iobenguane accumulation.
Conduite à tenir
Discontinue methyldopa for at least five half-lives before iobenguane dosimetry or therapy and do not resume until at least 7 days after each dose, using an alternative antihypertensive meanwhile.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Methyldopa
- Methyldopa + Tranylcypromine Contre-indiquée
- Lofexidine + Methyldopa Majeure
- Methyldopa + Pexidartinib Majeure
- Methyldopa + Pretomanid Majeure
- Methyldopa + Thioridazine Majeure
- Adrenaline-articaine + Methyldopa Modérée
Questions fréquentes
Can I take Iobenguane i with Methyldopa?
MediHelp rates the interaction as major. Iobenguane i and Methyldopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methyldopa interferes with catecholamine handling and may reduce uptake of iobenguane into target cells. This can lower its diagnostic or therapeutic efficacy.
How serious is the interaction between Iobenguane i and Methyldopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue methyldopa for at least five half-lives before iobenguane dosimetry or therapy and do not resume until at least 7 days after each dose, using an alternative antihypertensive meanwhile.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Lofexidine, Pexidartinib. The full list is on the Methyldopa page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
