Référentiel des médicaments
Mexiletine
Mexiletine is a medicine in the class cardiovascular. It is used for arrhythmias.
- Classe médicamenteuse: Cardiovascular
- Indications: arrhythmias
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Code ATC
- C01BB02
- Interactions connues
- 121 (Contre-indiquée: 2 · Majeure: 16 · Modérée: 75 · Mineure: 28)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Class 1B antidysrhythmic; combines with fast Na channels & thereby inhibits recovery after repolarization resulting in decreasing myocardial excitability & conduction velocity
Posologie adulte habituelle (résumé de la notice)
Ventricular Arrhythmias (Life-Threatening) Initial: 200 mg PO q8hr; may load with 400 mg followed by 200 mg PO q8hr if necessary for rapid control of ventricular arrhythmia
Grossesse et allaitement
- Grossesse
- Unknown No adequate human data. Animal studies showed no birth defects but more fetal loss (resorptions) at up to 4 times the human dose. Use only if the benefit outweighs the risk, for example for serious arrhythmias, with fetal monitoring.
- Allaitement
- Safe Passes into milk at levels similar to the mother's blood. US label: consider another way of feeding the infant. LactMed: doses up to 600 mg daily give low milk levels that are not expected to harm the infant.
Effets indésirables signalés
- Vomiting
- Nausea
- Dizziness
- Ataxia
- Heartburn
Mises en garde encadrées
- National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%) CAST was a long-term, multicenter, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction (MI) >6 days but <2 yr previously Average duration of treatment w/ encainide or flecainide in CAST was 10 months Applicability of CAST results to other populations (eg, patients without recent MI) is uncertain…
Contre-indications
- Hypersensitivity to mexiletine
- Cardiogenic shock, preexisting 2°/3° AV block without pacemaker
Précautions particulières
- Monitor and adjust dose to prevent QTc prolongation
- Use caution in CHF, hypotension, history of seizures
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (121)
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
- Dofetilide + Mexiletine Major
- Dronedarone + Mexiletine Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mexiletine Major
- Fluvoxamine + Mexiletine Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Mexiletine used for?
Mexiletine is a medicine in the class cardiovascular. It is used for Arrhythmias.
What side effects have been reported with Mexiletine?
Vomiting, Nausea, Dizziness, Ataxia, Heartburn. Serious warning: National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%) CAST was a long-term, multicenter, randomized, double-blind study in patients with…
Can Mexiletine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Animal studies showed no birth defects but more fetal loss (resorptions) at up to 4 times the human dose. Use only if the benefit outweighs the risk, for example for serious arrhythmias, with fetal monitoring. Breastfeeding: Safe. Passes into milk at levels similar to the mother's blood. US label: consider another way of feeding the infant. LactMed: doses up to 600 mg daily give low milk levels that are not expected to harm the infant.
What does Mexiletine interact with?
MediHelp lists 121 known interactions for Mexiletine. Contraindicated: 2 · Major: 16 · Moderate: 75 · Minor: 28. The most serious include Fezolinetant, Pimozide, Alosetron.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
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