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Interactions médicamenteuses

Fezolinetant + Mexiletine

Gravité: Contre-indiquée

Fezolinetant and Mexiletine: contraindicated interaction.

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Résumé

Fezolinetant is metabolized primarily by CYP1A2, and its exposure rises with CYP1A2 inhibitors. Mexiletine is a CYP1A2 inhibitor, so fezolinetant levels may increase, raising the risk of liver toxicity and other adverse effects. Labeling contraindicates use with CYP1A2 inhibitors.

Ce que signifie cette interaction, en termes simples

Fezolinetant and Mexiletine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fezolinetant belongs to Endocrine; Mexiletine belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Mexiletine inhibits CYP1A2, reducing fezolinetant clearance.

Conduite à tenir

Do not use together; choose another menopause vasomotor therapy. If mexiletine is required, stop fezolinetant.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fezolinetant with Mexiletine?

MediHelp rates the interaction as contraindicated. Fezolinetant and Mexiletine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized primarily by CYP1A2, and its exposure rises with CYP1A2 inhibitors. Mexiletine is a CYP1A2 inhibitor, so fezolinetant levels may increase, raising the risk of liver toxicity and other adverse effects. Labeling contraindicates use with CYP1A2 inhibitors.

How serious is the interaction between Fezolinetant and Mexiletine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose another menopause vasomotor therapy. If mexiletine is required, stop fezolinetant.

What other medicines interact with Mexiletine?

MediHelp also lists interactions of Mexiletine with, for example, Pimozide, Alosetron, Amiodarone. The full list is on the Mexiletine page.

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