Référentiel des médicaments
Nifurtimox
Nifurtimox is a medicine in the class anti parasitic.
- Classe médicamenteuse: Anti Parasitic
Dernière mise à jour Sources: US FDA label
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Anti Parasitic
- Formes courantes
- comprimé
- Noms commerciaux
- 1
- Pays et marchés
- 1
Mécanisme d'action
Mechanism not fully understood. Nifurtimox is activated by type I and type II nitroreductases, producing toxic intermediate metabolites and/or reactive oxygen species that induce DNA damage and cell death of intracellular and extracellular T. cruzi.
Grossesse et allaitement
- Grossesse
- Unsafe May cause fetal harm based on animal studies; treatment of chronic Chagas disease in pregnancy not recommended; acute symptomatic disease requires case-by-case risk-benefit evaluation.
- Allaitement
- Unknown Nifurtimox is present in breast milk (estimated infant dose less than 15% of the pediatric daily dose); monitor infants for vomiting, rash, decreased appetite, pyrexia and irritability; weigh benefits of breastfeeding against maternal need.
Effets indésirables signalés
- Vomiting
- Abdominal pain
- Headache
- Decreased appetite
- Nausea
- Pyrexia
Contre-indications
- Known hypersensitivity to nifurtimox or any excipients
- Alcohol consumption during treatment
Précautions particulières
- Genotoxicity demonstrated in humans, in vitro and in rodents; carcinogenicity in humans unknown.
- Embryo-fetal toxicity: can cause fetal harm; pregnancy test before treatment; effective contraception during treatment and for 6 months after; males use condoms during and for 3 months after.
- May worsen neurological and psychiatric conditions (brain injury, seizures, psychiatric disease); use under close medical supervision.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Nifurtimox used for?
Nifurtimox is a medicine in the class anti parasitic.
What side effects have been reported with Nifurtimox?
Vomiting, Abdominal pain, Headache, Decreased appetite, Nausea, Pyrexia.
Can Nifurtimox be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm based on animal studies; treatment of chronic Chagas disease in pregnancy not recommended; acute symptomatic disease requires case-by-case risk-benefit evaluation. Breastfeeding: Unknown. Nifurtimox is present in breast milk (estimated infant dose less than 15% of the pediatric daily dose); monitor infants for vomiting, rash, decreased appetite, pyrexia and irritability; weigh benefits of breastfeeding against maternal need.
What does Nifurtimox interact with?
MediHelp does not list a checked interaction for Nifurtimox yet. Always tell your pharmacist about every medicine you take.
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