Référentiel des médicaments
Secnidazole
Secnidazole is a medicine in the class anti parasitic. It is used for bacterial vaginosis.
- Classe médicamenteuse: Anti Parasitic
- Indications: bacterial vaginosis
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Anti Parasitic
- Formes courantes
- comprimé, sachet
- Dosages courants
- 500 mg, 1 g, 2 g/4.8 g
- Interactions connues
- 1 (Modérée: 1)
- Noms commerciaux
- 13
- Pays et marchés
- 4
Indications
Mécanisme d'action
Secnidazole is a nitroimidazole derivative; 5-nitroimidazoles enters the bacterial cell as an inactive prodrug where the nitro group is reduced by bacterial enzymes to radical anions. It is believed that these radical anions interfere with bacterial DNA synthesis of susceptible isolates
Posologie adulte habituelle (résumé de la notice)
Bacterial Vaginosis: 1 packet (2 grams) of granules or tablet PO once as a single dose, without regard to timing of meals
Grossesse et allaitement
- Grossesse
- Unknown Limited human data; no harm in rats or rabbits at up to 4 times the clinical dose. A nitroimidazole like metronidazole, which has far more pregnancy data and is preferred for bacterial vaginosis or trichomonas in pregnancy.
- Allaitement
- Unknown No human milk data; related drugs pass into milk. US label: breastfeeding not recommended during treatment and for 96 hours after the single dose (possible tumour risk in animals); pump and discard. LactMed: vaginal treatments give lower milk levels. e-lactancia: compatible.
Effets indésirables signalés
- Headache
- Vomiting
- Diarrhea
- Nausea
- Vulvovaginal candidiasis
- Dysgeusia
Contre-indications
- Hypersensitivity to secnidazole, excipients of the formulation, or other nitroimidazole derivatives
- Patients with Cockayne syndrome
Précautions particulières
- Severe irreversible hepatotoxicity/acute liver failure with fatal outcomes reported after initiation of metronidazole in patients with Cockayne syndrome
- Carcinogenicity has been seen in mice and rats treated long term with nitroimidazole derivatives, which are structurally related to secnidazole; avoid long-term use
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (1)
- Ethanol + Secnidazole Moderate
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- Paediatric dosing
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Questions fréquentes
What is Secnidazole used for?
Secnidazole is a medicine in the class anti parasitic. It is used for Bacterial vaginosis, Trichomoniasis.
What side effects have been reported with Secnidazole?
Headache, Vomiting, Diarrhea, Nausea, Vulvovaginal candidiasis, Dysgeusia.
Can Secnidazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data; no harm in rats or rabbits at up to 4 times the clinical dose. A nitroimidazole like metronidazole, which has far more pregnancy data and is preferred for bacterial vaginosis or trichomonas in pregnancy. Breastfeeding: Unknown. No human milk data; related drugs pass into milk. US label: breastfeeding not recommended during treatment and for 96 hours after the single dose (possible tumour risk in animals); pump and discard. LactMed: vaginal treatments give lower milk levels. e-lactancia: compatible.
What does Secnidazole interact with?
MediHelp lists 1 known interactions for Secnidazole. Moderate: 1. The most serious include Ethanol.
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