Référentiel des médicaments
Risankizumab
Risankizumab is a medicine in the class miscellaneous. It is used for crohn's disease.
- Classe médicamenteuse: Miscellaneous
- Indications: crohn's disease
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- L04AC18
- Formes courantes
- injection
- Dosages courants
- 150 mg/ml
- Interactions connues
- 2 (Majeure: 1 · Modérée: 1)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Humanized IgG1 monoclonal antibody that selectively binds the p19 subunit of human IL-23 and inhibits its interaction with the IL-23 receptor, reducing release of pro-inflammatory cytokines and chemokines.
Posologie adulte habituelle (résumé de la notice)
Plaque psoriasis: 150 mg, subcutaneous injection, at Week 0, Week 4, and every 12 weeks thereafter
Grossesse et allaitement
- Grossesse
- Unknown Data are insufficient to show a risk; a registry exists. Antibodies cross the placenta, mainly late in pregnancy, and may suppress the infant's immunity. Monkeys had more fetal and infant deaths at high doses. Use only if needed; delay live vaccines in exposed infants.
- Allaitement
- Safe No human milk data. A large antibody: milk levels are likely very low and it is probably digested in the infant's gut. Some expert guidelines consider it acceptable while breastfeeding (LactMed). US label: weigh benefits.
Effets indésirables signalés
- Upper respiratory infections
- Headache
- Fatigue
- Injection site reactions
- Tinea infections
- Arthralgia
Contre-indications
- History of serious hypersensitivity reaction to risankizumab-rzaa or any excipients.
Précautions particulières
- Serious hypersensitivity reactions including anaphylaxis may occur; discontinue and treat immediately if it occurs.
- May increase risk of infection; do not start in clinically important active infection and withhold if one develops until resolved.
- Evaluate for TB before initiating; do not give to patients with active TB; monitor for TB signs during and after treatment.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (2)
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Risankizumab used for?
Risankizumab is a medicine in the class miscellaneous. It is used for Crohn's disease, Plaque psoriasis, Psoriatic arthritis, Ulcerative colitis.
What side effects have been reported with Risankizumab?
Upper respiratory infections, Headache, Fatigue, Injection site reactions, Tinea infections, Arthralgia.
Can Risankizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Data are insufficient to show a risk; a registry exists. Antibodies cross the placenta, mainly late in pregnancy, and may suppress the infant's immunity. Monkeys had more fetal and infant deaths at high doses. Use only if needed; delay live vaccines in exposed infants. Breastfeeding: Safe. No human milk data. A large antibody: milk levels are likely very low and it is probably digested in the infant's gut. Some expert guidelines consider it acceptable while breastfeeding (LactMed). US label: weigh benefits.
What does Risankizumab interact with?
MediHelp lists 2 known interactions for Risankizumab. Major: 1 · Moderate: 1. The most serious include Upadacitinib, Measles mumps and rubella vaccine.
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