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Interactions médicamenteuses

Risankizumab + Upadacitinib

Gravité: Majeure

Risankizumab and Upadacitinib: major interaction.

Dernière mise à jour

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Résumé

Risankizumab blocks IL-23 and upadacitinib inhibits JAK signaling. They are sometimes considered together in inflammatory bowel disease, but combined immunosuppression may increase infection risk and data on safety are limited.

Ce que signifie cette interaction, en termes simples

Risankizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Risankizumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.

Niveau de preuve: Low

Pourquoi elle survient

Additive immunosuppression through IL-23 blockade and JAK inhibition.

Conduite à tenir

Avoid routine combination; if used, screen for tuberculosis and hepatitis beforehand and monitor for infections.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Risankizumab with Upadacitinib?

MediHelp rates the interaction as major. Risankizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Risankizumab blocks IL-23 and upadacitinib inhibits JAK signaling. They are sometimes considered together in inflammatory bowel disease, but combined immunosuppression may increase infection risk and data on safety are limited.

How serious is the interaction between Risankizumab and Upadacitinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, screen for tuberculosis and hepatitis beforehand and monitor for infections.

What other medicines interact with Upadacitinib?

MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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