Référentiel des médicaments
Roflumilast
Roflumilast is a medicine in the class respiratory. It is used for copd.
- Classe médicamenteuse: Respiratory
- Indications: copd
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Respiratory
- Code ATC
- R03DX07
- Formes courantes
- comprimé, crème, inhalateur
- Dosages courants
- 500 mcg, 0.5 mg
- Interactions connues
- 64 (Majeure: 12 · Modérée: 41 · Mineure: 11)
- Noms commerciaux
- 10
- Pays et marchés
- 5
Indications
Mécanisme d'action
Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system.
Posologie adulte habituelle (résumé de la notice)
COPD: 500 mcg orally once every Day.
Grossesse et allaitement
- Grossesse
- Unknown No adequate human data. No malformations in rats or rabbits; pregnancy loss, stillbirth and poorer pup survival at 10 to 49 times the human dose, and it disrupted labour in mice. EU label: not recommended in pregnancy; US: do not use during labour and delivery.
- Allaitement
- Unknown No human data; it passes into rat milk. US and EU labels: should not be used while breastfeeding. LactMed: over 97% protein bound, so milk levels are probably very low, but the oral drug is best avoided. Cream: use on small areas only, not on the breast.
Effets indésirables signalés
- Headache
- Diarrhea
- Nausea
- Weight loss
Contre-indications
- Hypersensitivity
- Moderate-to-severe liver impairment (Child-Pugh class B or C)
Précautions particulières
- You should not use roflumilast if you have moderate or severe liver disease.
- You may take roflumilast with or without food.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (64)
- Apalutamide + Roflumilast Major
- Carbamazepine + Roflumilast Major
- Efavirenz + Roflumilast Major
- Enzalutamide + Roflumilast Major
- Fosphenytoin + Roflumilast Major
- Pentobarbital + Roflumilast Major
- Phenobarbital + Roflumilast Major
- Phenytoin + Roflumilast Major
- Primidone + Roflumilast Major
- Rifampin + Roflumilast Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Roflumilast used for?
Roflumilast is a medicine in the class respiratory. It is used for COPD, Scalp psoriasis.
What side effects have been reported with Roflumilast?
Headache, Diarrhea, Nausea, Weight loss.
Can Roflumilast be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. No malformations in rats or rabbits; pregnancy loss, stillbirth and poorer pup survival at 10 to 49 times the human dose, and it disrupted labour in mice. EU label: not recommended in pregnancy; US: do not use during labour and delivery. Breastfeeding: Unknown. No human data; it passes into rat milk. US and EU labels: should not be used while breastfeeding. LactMed: over 97% protein bound, so milk levels are probably very low, but the oral drug is best avoided. Cream: use on small areas only, not on the breast.
What does Roflumilast interact with?
MediHelp lists 64 known interactions for Roflumilast. Major: 12 · Moderate: 41 · Minor: 11. The most serious include Apalutamide, Carbamazepine, Efavirenz.
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