Interactions médicamenteuses
Fosphenytoin + Roflumilast
Gravité: Majeure
Fosphenytoin and Roflumilast: major interaction.
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Résumé
Fosphenytoin is converted to phenytoin, which induces CYP3A4 and CYP1A2 and substantially reduces roflumilast exposure. Therapeutic effect may be lost.
Ce que signifie cette interaction, en termes simples
Fosphenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fosphenytoin belongs to Central Nervous System; Roflumilast belongs to Respiratory.
Pourquoi elle survient
Phenytoin induces CYP3A4 and CYP1A2, increasing roflumilast clearance.
Conduite à tenir
Avoid the combination where possible, as the label advises against strong inducers. If both are required, monitor COPD control closely and consider an alternative to roflumilast.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Roflumilast
- Apalutamide + Roflumilast Majeure
- Carbamazepine + Roflumilast Majeure
- Efavirenz + Roflumilast Majeure
- Enzalutamide + Roflumilast Majeure
- Pentobarbital + Roflumilast Majeure
- Phenobarbital + Roflumilast Majeure
Autres interactions de Fosphenytoin
- Dronedarone + Fosphenytoin Contre-indiquée
- Fosphenytoin + Ledipasvir-sofosbuvir Contre-indiquée
- Fosphenytoin + Lorlatinib Contre-indiquée
- Fosphenytoin + Lurasidone Contre-indiquée
- Fosphenytoin + Ranolazine Contre-indiquée
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contre-indiquée
Questions fréquentes
Can I take Fosphenytoin with Roflumilast?
MediHelp rates the interaction as major. Fosphenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosphenytoin is converted to phenytoin, which induces CYP3A4 and CYP1A2 and substantially reduces roflumilast exposure. Therapeutic effect may be lost.
How serious is the interaction between Fosphenytoin and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as the label advises against strong inducers. If both are required, monitor COPD control closely and consider an alternative to roflumilast.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
