Référentiel des médicaments
Vandetanib
Vandetanib is a medicine in the class oncology. It is used for thyroid cancer.
- Classe médicamenteuse: Oncology
- Indications: thyroid cancer
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Oncology
- Formes courantes
- comprimé
- Interactions connues
- 137 (Contre-indiquée: 42 · Majeure: 71 · Modérée: 20 · Mineure: 4)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Vandetanib inhibits the tyrosine kinase activity of the EGFR and VEGFR families, RET, BRK, TIE2, and members of the EPH receptor and Src kinase families.
Posologie adulte habituelle (résumé de la notice)
Medullary thyroid cancer (symptomatic or progressive, unresectable locally advanced or metastatic): 300 mg orally once daily until disease progression or unacceptable toxicity
Grossesse et allaitement
- Grossesse
- Unsafe Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception.
- Allaitement
- Unsafe No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.
Effets indésirables signalés
- Diarrhea/colitis
- Rash
- Acneiform dermatitis
- Hypertension
- Nausea
- Headache
Mises en garde encadrées
- Can prolong the QT interval; torsades de pointes and sudden death have occurred. Do not use in patients with hypocalcemia, hypokalemia, hypomagnesemia, or long QT syndrome. Correct hypocalcemia, hypokalemia and/or hypomagnesemia before administration, monitor electrolytes periodically, and avoid drugs known to prolong the QT interval.
Contre-indications
- Congenital long QT syndrome
Précautions particulières
- QT prolongation: do not start if QTcF >450 ms; obtain ECG and potassium, calcium, magnesium and TSH at baseline, 2 to 4 weeks, 8 to 12 weeks, then every 3 months.
- Severe, sometimes fatal skin reactions including TEN and Stevens-Johnson syndrome; permanently discontinue for severe reactions. Photosensitivity can occur up to 4 months after discontinuation.
- Interstitial lung disease/pneumonitis, including fatalities; discontinue if confirmed.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (137)
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
- Chlorpromazine + Vandetanib Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Citalopram + Vandetanib Contraindicated
- Clomipramine + Vandetanib Contraindicated
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour ouvrir la monographie complète de Vandetanib : posologie, grossesse et allaitement, effets indésirables, mises en garde et toutes les interactions.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres médicaments de cette classe
Questions fréquentes
What is Vandetanib used for?
Vandetanib is a medicine in the class oncology. It is used for Thyroid cancer.
What side effects have been reported with Vandetanib?
Diarrhea/colitis, Rash, Acneiform dermatitis, Hypertension, Nausea, Headache. Serious warning: Can prolong the QT interval; torsades de pointes and sudden death have occurred.
Can Vandetanib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception. Breastfeeding: Unsafe. No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.
What does Vandetanib interact with?
MediHelp lists 137 known interactions for Vandetanib. Contraindicated: 42 · Major: 71 · Moderate: 20 · Minor: 4. The most serious include Amiodarone, Amisulpride, Amitriptyline.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
