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Interactions médicamenteuses

Amiodarone + Vandetanib

Gravité: Contre-indiquée

Amiodarone and Vandetanib: contraindicated interaction.

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Résumé

Vandetanib markedly prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. With amiodarone, whose half-life is very long, the risk of torsades de pointes and sudden death is significantly increased.

Ce que signifie cette interaction, en termes simples

Amiodarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Vandetanib belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Additive QT prolongation through repolarizing potassium channel blockade.

Conduite à tenir

Avoid the combination and choose an alternative therapy. Do not start vandetanib while amiodarone is still present in the body unless benefits clearly outweigh risks, with close ECG and electrolyte monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Vandetanib?

MediHelp rates the interaction as contraindicated. Amiodarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib markedly prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. With amiodarone, whose half-life is very long, the risk of torsades de pointes and sudden death is significantly increased.

How serious is the interaction between Amiodarone and Vandetanib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative therapy. Do not start vandetanib while amiodarone is still present in the body unless benefits clearly outweigh risks, with close ECG and electrolyte monitoring.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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