Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Chlorpromazine + Vandetanib

Gravité: Contre-indiquée

Chlorpromazine and Vandetanib: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Vandetanib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes and sudden death. Adding chlorpromazine, which also prolongs QT, further increases this risk.

Ce que signifie cette interaction, en termes simples

Chlorpromazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Chlorpromazine belongs to Central Nervous System; Vandetanib belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Additive blockade of cardiac potassium channels leading to QT prolongation.

Conduite à tenir

Avoid concurrent use and choose a non-QT-prolonging alternative to chlorpromazine. If it cannot be avoided, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Chlorpromazine et Vandetanib, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Chlorpromazine with Vandetanib?

MediHelp rates the interaction as contraindicated. Chlorpromazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes and sudden death. Adding chlorpromazine, which also prolongs QT, further increases this risk.

How serious is the interaction between Chlorpromazine and Vandetanib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging alternative to chlorpromazine. If it cannot be avoided, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter