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Interactions médicamenteuses

Abciximab + Caplacizumab

Gravité: Majeure

Abciximab and Caplacizumab: major interaction.

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Résumé

Caplacizumab blocks von Willebrand factor-platelet binding and abciximab blocks platelet aggregation, so combined use increases bleeding risk. Serious bleeding including mucosal and intracranial hemorrhage is possible.

Ce que signifie cette interaction, en termes simples

Abciximab and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Abciximab belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive inhibition of platelet adhesion (anti-vWF A1 domain) and aggregation (GP IIb/IIIa blockade).

Conduite à tenir

Avoid the combination where possible; if necessary, monitor closely for bleeding and withhold caplacizumab if clinically significant bleeding occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Abciximab with Caplacizumab?

MediHelp rates the interaction as major. Abciximab and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-platelet binding and abciximab blocks platelet aggregation, so combined use increases bleeding risk. Serious bleeding including mucosal and intracranial hemorrhage is possible.

How serious is the interaction between Abciximab and Caplacizumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if necessary, monitor closely for bleeding and withhold caplacizumab if clinically significant bleeding occurs.

What other medicines interact with Abciximab?

MediHelp also lists interactions of Abciximab with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Abciximab page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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