Référentiel des médicaments
Caplacizumab
Caplacizumab is a medicine in the class cardiovascular. It is used for thrombocytopenic purpura.
- Classe médicamenteuse: Cardiovascular
- Indications: thrombocytopenic purpura
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Dosages courants
- 10 mg
- Interactions connues
- 19 (Majeure: 17 · Modérée: 2)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Targets the A1-domain of von Willebrand factor (vWF) and inhibits the interaction between vWF and platelets, reducing vWF-mediated platelet adhesion and platelet consumption.
Posologie adulte habituelle (résumé de la notice)
aTTP, first day: 11 mg bolus intravenous injection at least 15 minutes prior to plasma exchange, then 11 mg subcutaneous injection after completion of plasma exchange on day 1
Grossesse et allaitement
- Grossesse
- Unknown No human data. It raises bleeding risk, so mother and fetus or newborn may bleed, especially around delivery. Guinea pig studies showed no developmental harm. Use if needed for TTP; monitor mother and newborn for bleeding.
- Allaitement
- Unknown No milk data. LactMed: as a protein, milk levels are likely very low and it is probably digested in the infant gut; use with caution, especially with a newborn. Some advise not breastfeeding with acquired TTP. Weigh benefit.
Effets indésirables signalés
- Epistaxis
- Headache
- Gingival bleeding
- Fatigue
- Urticaria
- Pyrexia
Contre-indications
- Previous severe hypersensitivity reaction to caplacizumab-yhdp or any of the excipients.
Précautions particulières
- Hemorrhage: serious and fatal bleeding can occur; risk increased with underlying coagulopathies or drugs affecting hemostasis. Interrupt if clinically significant bleeding occurs; von Willebrand factor concentrate may be given to correct hemostasis.
- Withhold for 7 days before elective surgery or invasive interventions; monitor closely for bleeding after resuming.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (19)
- Abciximab + Caplacizumab Major
- Acetylsalicylic acid + Caplacizumab Major
- Alteplase + Caplacizumab Major
- Anagrelide + Caplacizumab Major
- Apixaban + Caplacizumab Major
- Argatroban + Caplacizumab Major
- Caplacizumab + Clopidogrel Major
- Caplacizumab + Dabigatran etexilate Major
- Caplacizumab + Dalteparin Major
- Caplacizumab + Edoxaban Major
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour ouvrir la monographie complète de Caplacizumab : posologie, grossesse et allaitement, effets indésirables, mises en garde et toutes les interactions.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres médicaments de cette classe
Questions fréquentes
What is Caplacizumab used for?
Caplacizumab is a medicine in the class cardiovascular. It is used for Thrombocytopenic purpura.
What side effects have been reported with Caplacizumab?
Epistaxis, Headache, Gingival bleeding, Fatigue, Urticaria, Pyrexia.
Can Caplacizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. It raises bleeding risk, so mother and fetus or newborn may bleed, especially around delivery. Guinea pig studies showed no developmental harm. Use if needed for TTP; monitor mother and newborn for bleeding. Breastfeeding: Unknown. No milk data. LactMed: as a protein, milk levels are likely very low and it is probably digested in the infant gut; use with caution, especially with a newborn. Some advise not breastfeeding with acquired TTP. Weigh benefit.
What does Caplacizumab interact with?
MediHelp lists 19 known interactions for Caplacizumab. Major: 17 · Moderate: 2. The most serious include Abciximab, Acetylsalicylic acid, Alteplase.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
