Interactions médicamenteuses
Alteplase + Caplacizumab
Gravité: Majeure
Alteplase and Caplacizumab: major interaction.
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Résumé
Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and thrombolysis with alteplase adds fibrinolytic activity. Together they substantially raise the risk of severe bleeding.
Ce que signifie cette interaction, en termes simples
Alteplase and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alteplase belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.
Pourquoi elle survient
Additive pharmacodynamic effect of impaired platelet adhesion and plasmin-mediated fibrin breakdown.
Conduite à tenir
Avoid concurrent use unless thrombolysis is clearly essential; if so, withhold caplacizumab and monitor closely for bleeding with ready access to supportive care.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Alteplase
- Alteplase + Defibrotide Contre-indiquée
- Alteplase + Reteplase Contre-indiquée
- Alteplase + Tenecteplase Contre-indiquée
- Acetylsalicylic acid + Alteplase Majeure
- Alteplase + Apixaban Majeure
- Alteplase + Argatroban Majeure
Autres interactions de Caplacizumab
- Abciximab + Caplacizumab Majeure
- Acetylsalicylic acid + Caplacizumab Majeure
- Anagrelide + Caplacizumab Majeure
- Apixaban + Caplacizumab Majeure
- Argatroban + Caplacizumab Majeure
- Caplacizumab + Clopidogrel Majeure
Questions fréquentes
Can I take Alteplase with Caplacizumab?
MediHelp rates the interaction as major. Alteplase and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and thrombolysis with alteplase adds fibrinolytic activity. Together they substantially raise the risk of severe bleeding.
How serious is the interaction between Alteplase and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless thrombolysis is clearly essential; if so, withhold caplacizumab and monitor closely for bleeding with ready access to supportive care.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
