Interactions médicamenteuses
Abiraterone + Rifapentine
Gravité: Majeure
Abiraterone and Rifapentine: major interaction.
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Résumé
Rifapentine induces CYP3A4 and is expected to lower abiraterone concentrations. This could reduce its effectiveness against prostate cancer.
Ce que signifie cette interaction, en termes simples
Abiraterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abiraterone belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Pourquoi elle survient
Rifapentine induces CYP3A4, accelerating abiraterone metabolism.
Conduite à tenir
Avoid if possible. If required, increase abiraterone to twice daily during rifapentine therapy and monitor PSA and clinical response.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Abiraterone
- Abiraterone + Radium-223 dichloride Contre-indiquée
- Abiraterone + Thioridazine Contre-indiquée
- Abiraterone + Amobarbital Majeure
- Abiraterone + Carbamazepine Majeure
- Abiraterone + Dabrafenib Majeure
- Abiraterone + Desipramine Majeure
Autres interactions de Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contre-indiquée
- Lorlatinib + Rifapentine Contre-indiquée
- Lurasidone + Rifapentine Contre-indiquée
- Ranolazine + Rifapentine Contre-indiquée
- Rifapentine + Sofosbuvir-velpatasvir Contre-indiquée
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contre-indiquée
Questions fréquentes
Can I take Abiraterone with Rifapentine?
MediHelp rates the interaction as major. Abiraterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine induces CYP3A4 and is expected to lower abiraterone concentrations. This could reduce its effectiveness against prostate cancer.
How serious is the interaction between Abiraterone and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If required, increase abiraterone to twice daily during rifapentine therapy and monitor PSA and clinical response.
What other medicines interact with Abiraterone?
MediHelp also lists interactions of Abiraterone with, for example, Radium-223 dichloride, Thioridazine, Amobarbital. The full list is on the Abiraterone page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
