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Interactions médicamenteuses

Rifapentine + Sofosbuvir-velpatasvir

Gravité: Contre-indiquée

Rifapentine and Sofosbuvir-velpatasvir: contraindicated interaction.

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Résumé

Rifapentine is a strong inducer of CYP3A4 and P-gp and is expected to substantially reduce velpatasvir and sofosbuvir levels. This may lead to HCV treatment failure.

Ce que signifie cette interaction, en termes simples

Rifapentine and Sofosbuvir-velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Rifapentine belongs to Anti Bacterial; Sofosbuvir-velpatasvir belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Rifapentine induces P-gp and CYP3A4/2B6/2C8, increasing antiviral clearance.

Conduite à tenir

Avoid concurrent use and defer HCV therapy until rifapentine is finished, or choose a different TB regimen.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Rifapentine with Sofosbuvir-velpatasvir?

MediHelp rates the interaction as contraindicated. Rifapentine and Sofosbuvir-velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is a strong inducer of CYP3A4 and P-gp and is expected to substantially reduce velpatasvir and sofosbuvir levels. This may lead to HCV treatment failure.

How serious is the interaction between Rifapentine and Sofosbuvir-velpatasvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and defer HCV therapy until rifapentine is finished, or choose a different TB regimen.

What other medicines interact with Sofosbuvir-velpatasvir?

MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, St john's wort, Amiodarone. The full list is on the Sofosbuvir-velpatasvir page.

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