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Interactions médicamenteuses

Ledipasvir-sofosbuvir + Rifapentine

Gravité: Contre-indiquée

Ledipasvir-sofosbuvir and Rifapentine: contraindicated interaction.

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Résumé

Rifapentine is an inducer of P-glycoprotein and metabolic enzymes and is expected to lower sofosbuvir and ledipasvir exposure, risking loss of virologic response.

Ce que signifie cette interaction, en termes simples

Ledipasvir-sofosbuvir and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ledipasvir-sofosbuvir belongs to Anti Virals; Rifapentine belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Rifapentine induces intestinal P-glycoprotein, reducing absorption and plasma concentrations of sofosbuvir and ledipasvir.

Conduite à tenir

Avoid concurrent use. Delay hepatitis C therapy until rifapentine is completed, or use an alternative antimycobacterial regimen.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ledipasvir-sofosbuvir with Rifapentine?

MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is an inducer of P-glycoprotein and metabolic enzymes and is expected to lower sofosbuvir and ledipasvir exposure, risking loss of virologic response.

How serious is the interaction between Ledipasvir-sofosbuvir and Rifapentine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Delay hepatitis C therapy until rifapentine is completed, or use an alternative antimycobacterial regimen.

What other medicines interact with Ledipasvir-sofosbuvir?

MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.

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