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Interactions médicamenteuses

Lorlatinib + Rifapentine

Gravité: Contre-indiquée

Lorlatinib and Rifapentine: contraindicated interaction.

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Résumé

Rifapentine is a strong CYP3A4 inducer that can substantially lower lorlatinib levels, risking loss of efficacy. Combination with rifampin-type inducers has been associated with hepatotoxicity, and labeling contraindicates strong inducers.

Ce que signifie cette interaction, en termes simples

Lorlatinib and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lorlatinib belongs to Oncology; Rifapentine belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Induction of CYP3A4 increases lorlatinib metabolism.

Conduite à tenir

Avoid the combination and select a non-inducing alternative. Allow adequate washout of rifapentine before starting lorlatinib.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lorlatinib with Rifapentine?

MediHelp rates the interaction as contraindicated. Lorlatinib and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is a strong CYP3A4 inducer that can substantially lower lorlatinib levels, risking loss of efficacy. Combination with rifampin-type inducers has been associated with hepatotoxicity, and labeling contraindicates strong inducers.

How serious is the interaction between Lorlatinib and Rifapentine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-inducing alternative. Allow adequate washout of rifapentine before starting lorlatinib.

What other medicines interact with Lorlatinib?

MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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