Interactions médicamenteuses
Abobotulinumtoxina + Trihexyphenidyl
Gravité: Modérée
Abobotulinumtoxina and Trihexyphenidyl: moderate interaction.
Dernière mise à jour
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Résumé
Systemic anticholinergics may add to the effects of botulinum toxin on cholinergic transmission. This could increase anticholinergic adverse effects, and in theory spread of weakness beyond the injection site. The clinical significance is generally modest at standard doses.
Ce que signifie cette interaction, en termes simples
Abobotulinumtoxina and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Botulinum toxin blocks acetylcholine release presynaptically while trihexyphenidyl blocks muscarinic receptors, giving additive cholinergic inhibition.
Conduite à tenir
Monitor for generalized weakness, swallowing or breathing difficulty and systemic anticholinergic effects after injection. Use the lowest effective toxin dose.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Trihexyphenidyl
- Orphenadrin + Trihexyphenidyl Majeure
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- Trihexyphenidyl + Trospium Majeure
- Aclidinium + Trihexyphenidyl Modérée
Questions fréquentes
Can I take Abobotulinumtoxina with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Abobotulinumtoxina and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic anticholinergics may add to the effects of botulinum toxin on cholinergic transmission. This could increase anticholinergic adverse effects, and in theory spread of weakness beyond the injection site. The clinical significance is generally modest at standard doses.
How serious is the interaction between Abobotulinumtoxina and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for generalized weakness, swallowing or breathing difficulty and systemic anticholinergic effects after injection. Use the lowest effective toxin dose.
What other medicines interact with Trihexyphenidyl?
MediHelp also lists interactions of Trihexyphenidyl with, for example, Orphenadrin, Oxybutynin, Scopolamine. The full list is on the Trihexyphenidyl page.
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