Interactions médicamenteuses
Aclidinium + Trihexyphenidyl
Gravité: Modérée
Aclidinium and Trihexyphenidyl: moderate interaction.
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Résumé
Aclidinium is an inhaled antimuscarinic with low systemic absorption, though some systemic exposure occurs. With trihexyphenidyl, additive anticholinergic effects such as dry mouth, urinary retention, constipation and ocular effects may occur.
Ce que signifie cette interaction, en termes simples
Aclidinium and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Additive muscarinic receptor antagonism.
Conduite à tenir
Avoid regular concurrent use of other anticholinergics with aclidinium where possible. Monitor for urinary retention, constipation and worsening glaucoma symptoms.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Questions fréquentes
Can I take Aclidinium with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Aclidinium and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aclidinium is an inhaled antimuscarinic with low systemic absorption, though some systemic exposure occurs. With trihexyphenidyl, additive anticholinergic effects such as dry mouth, urinary retention, constipation and ocular effects may occur.
How serious is the interaction between Aclidinium and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use of other anticholinergics with aclidinium where possible. Monitor for urinary retention, constipation and worsening glaucoma symptoms.
What other medicines interact with Trihexyphenidyl?
MediHelp also lists interactions of Trihexyphenidyl with, for example, Orphenadrin, Oxybutynin, Scopolamine. The full list is on the Trihexyphenidyl page.
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