Référentiel des médicaments
Trihexyphenidyl
Trihexyphenidyl is a medicine in the class central nervous system. It is used for parkinson disease.
- Classe médicamenteuse: Central Nervous System
- Indications: parkinson disease
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Autres noms
- Benzhexol
- Dosages courants
- 5 mg, 2 mg
- Interactions connues
- 89 (Majeure: 5 · Modérée: 77 · Mineure: 7)
- Noms commerciaux
- 3
- Pays et marchés
- 1
Indications
Mécanisme d'action
Trihexyphenidyl inhibits the parasympathetic nervous system and has a relaxing effect on smooth muscles
Posologie adulte habituelle (résumé de la notice)
Parkinson Disease Initial: 1 mg PO first day, then increase by 2 mg q3-5days until reach 6-10 mg/days
Grossesse et allaitement
- Grossesse
- Unknown Limited human data and no animal studies; no clear pattern of birth defects. Near term, anticholinergics given with antipsychotics have caused newborn bowel problems (paralytic ileus). US label: only if clearly needed. Use the lowest dose and tell the delivery team.
- Allaitement
- Unknown Limited data: up to 4 mg daily with haloperidol or risperidone caused no infant effects. LactMed: long-term use might reduce milk production or let-down (less likely with antipsychotics that raise prolactin); watch milk supply and infant weight gain.
Effets indésirables signalés
- Rash
- Anticholinergic side effects
- Suppurative parotitis
- Hallucination
Précautions particulières
- Exacerbation of parkinsonism, neuroleptic malignant syndrome, and withdrawal symptoms results of therapy discontinuation or dose reduction; should be withdrawn gradually
- Use extreme caution and monitor closely patients with liver, cardiac, kidney disorders, prostatic hyperplasia (urinary stricture), or with hypertension
- Drug has atropine-like properties; use with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts and in elderly males
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (89)
- Orphenadrin + Trihexyphenidyl Major
- Oxybutynin + Trihexyphenidyl Major
- Scopolamine + Trihexyphenidyl Major
- Solifenacin + Trihexyphenidyl Major
- Trihexyphenidyl + Trospium Major
- Abobotulinumtoxina + Trihexyphenidyl Moderate
- Aclidinium + Trihexyphenidyl Moderate
- Amantadine + Trihexyphenidyl Moderate
- Amitriptyline + Trihexyphenidyl Moderate
- Amoxapine + Trihexyphenidyl Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Dosing in older adults
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Trihexyphenidyl used for?
Trihexyphenidyl is a medicine in the class central nervous system. It is used for Parkinson disease.
What side effects have been reported with Trihexyphenidyl?
Rash, Anticholinergic side effects, Suppurative parotitis, Hallucination.
Can Trihexyphenidyl be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data and no animal studies; no clear pattern of birth defects. Near term, anticholinergics given with antipsychotics have caused newborn bowel problems (paralytic ileus). US label: only if clearly needed. Use the lowest dose and tell the delivery team. Breastfeeding: Unknown. Limited data: up to 4 mg daily with haloperidol or risperidone caused no infant effects. LactMed: long-term use might reduce milk production or let-down (less likely with antipsychotics that raise prolactin); watch milk supply and infant weight gain.
What does Trihexyphenidyl interact with?
MediHelp lists 89 known interactions for Trihexyphenidyl. Major: 5 · Moderate: 77 · Minor: 7. The most serious include Orphenadrin, Oxybutynin, Scopolamine.
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