Interactions médicamenteuses
Solifenacin + Trihexyphenidyl
Gravité: Majeure
Solifenacin and Trihexyphenidyl: major interaction.
Dernière mise à jour
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Résumé
Both drugs are antimuscarinic, so combined use can produce marked dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are especially vulnerable to cognitive impairment and delirium.
Ce que signifie cette interaction, en termes simples
Solifenacin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Solifenacin belongs to Genitourinary; Trihexyphenidyl belongs to Central Nervous System.
Pourquoi elle survient
Additive antagonism of muscarinic receptors.
Conduite à tenir
Avoid the combination where possible, particularly in older adults. If necessary, use the lowest effective doses and monitor for urinary retention, constipation and cognitive changes.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Solifenacin
- Adagrasib + Solifenacin Majeure
- Amiodarone + Solifenacin Majeure
- Amisulpride + Solifenacin Majeure
- Anagrelide + Solifenacin Majeure
- Arsenic trioxide + Solifenacin Majeure
- Bedaquiline + Solifenacin Majeure
Autres interactions de Trihexyphenidyl
- Orphenadrin + Trihexyphenidyl Majeure
- Oxybutynin + Trihexyphenidyl Majeure
- Scopolamine + Trihexyphenidyl Majeure
- Trihexyphenidyl + Trospium Majeure
- Abobotulinumtoxina + Trihexyphenidyl Modérée
- Aclidinium + Trihexyphenidyl Modérée
Questions fréquentes
Can I take Solifenacin with Trihexyphenidyl?
MediHelp rates the interaction as major. Solifenacin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are antimuscarinic, so combined use can produce marked dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are especially vulnerable to cognitive impairment and delirium.
How serious is the interaction between Solifenacin and Trihexyphenidyl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in older adults. If necessary, use the lowest effective doses and monitor for urinary retention, constipation and cognitive changes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
