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Interactions médicamenteuses

Acetylsalicylic acid + Hydrocortisone

Gravité: Modérée

Acetylsalicylic acid and Hydrocortisone: moderate interaction.

Dernière mise à jour

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Résumé

Systemic corticosteroids combined with aspirin increase the risk of gastric ulceration and gastrointestinal bleeding. Corticosteroids may also lower salicylate levels, which can rise when the steroid is withdrawn.

Ce que signifie cette interaction, en termes simples

Acetylsalicylic acid and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Acetylsalicylic acid belongs to Musculoskeletal; Hydrocortisone belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive gastric mucosal injury, plus corticosteroid-induced increase in salicylate clearance.

Conduite à tenir

Consider a proton pump inhibitor in patients with ulcer risk factors. Monitor for GI bleeding and for salicylate toxicity when steroids are tapered at high aspirin doses.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Acetylsalicylic acid with Hydrocortisone?

MediHelp rates the interaction as moderate. Acetylsalicylic acid and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids combined with aspirin increase the risk of gastric ulceration and gastrointestinal bleeding. Corticosteroids may also lower salicylate levels, which can rise when the steroid is withdrawn.

How serious is the interaction between Acetylsalicylic acid and Hydrocortisone?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in patients with ulcer risk factors. Monitor for GI bleeding and for salicylate toxicity when steroids are tapered at high aspirin doses.

What other medicines interact with Acetylsalicylic acid?

MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.

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