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Interactions médicamenteuses

Hydrocortisone + Mifepristone

Gravité: Contre-indiquée

Hydrocortisone and Mifepristone: contraindicated interaction.

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Résumé

Mifepristone blocks the glucocorticoid receptor, so it counteracts hydrocortisone and can precipitate adrenal insufficiency in patients on long-term corticosteroid replacement or treatment. Loss of steroid effect may cause hypotension and hypoglycaemia.

Ce que signifie cette interaction, en termes simples

Hydrocortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Hydrocortisone belongs to Endocrine; Mifepristone belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Glucocorticoid receptor antagonism opposes hydrocortisone effect

Conduite à tenir

Contraindicated with long-term corticosteroid therapy; consider an alternative and do not use mifepristone to treat patients depending on hydrocortisone.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Hydrocortisone with Mifepristone?

MediHelp rates the interaction as contraindicated. Hydrocortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone blocks the glucocorticoid receptor, so it counteracts hydrocortisone and can precipitate adrenal insufficiency in patients on long-term corticosteroid replacement or treatment. Loss of steroid effect may cause hypotension and hypoglycaemia.

How serious is the interaction between Hydrocortisone and Mifepristone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated with long-term corticosteroid therapy; consider an alternative and do not use mifepristone to treat patients depending on hydrocortisone.

What other medicines interact with Hydrocortisone?

MediHelp also lists interactions of Hydrocortisone with, for example, Poliovirus vaccine live oral trivalent, Smallpox vaccine live, Adenovirus types 4 and 7 live. The full list is on the Hydrocortisone page.

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