Interactions médicamenteuses
Hydrocortisone + Smallpox vaccine live
Gravité: Contre-indiquée
Hydrocortisone and Smallpox vaccine live: contraindicated interaction.
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Résumé
Live vaccinia vaccine can cause progressive vaccinia and other severe complications in immunocompromised patients. Corticosteroid immunosuppression increases this risk and may reduce vaccine take.
Ce que signifie cette interaction, en termes simples
Hydrocortisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Corticosteroid-induced immunosuppression allows uncontrolled replication of live vaccinia virus.
Conduite à tenir
Avoid in patients on immunosuppressive corticosteroids unless the benefit clearly outweighs risk, such as in post-exposure outbreak settings, and seek specialist advice. Use a non-replicating vaccine if available.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Hydrocortisone
- Hydrocortisone + Mifepristone Contre-indiquée
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contre-indiquée
- Adenovirus types 4 and 7 live + Hydrocortisone Majeure
- Aldesleukin + Hydrocortisone Majeure
- Aspirin + Hydrocortisone Majeure
- Bcg vaccine live + Hydrocortisone Majeure
Questions fréquentes
Can I take Hydrocortisone with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Hydrocortisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and other severe complications in immunocompromised patients. Corticosteroid immunosuppression increases this risk and may reduce vaccine take.
How serious is the interaction between Hydrocortisone and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients on immunosuppressive corticosteroids unless the benefit clearly outweighs risk, such as in post-exposure outbreak settings, and seek specialist advice. Use a non-replicating vaccine if available.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Adenovirus types 4 and 7 live. The full list is on the Hydrocortisone page.
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