Interactions médicamenteuses
Aclidinium + Umeclidinium-vilanterol
Gravité: Majeure
Aclidinium and Umeclidinium-vilanterol: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Aclidinium and umeclidinium are both long-acting antimuscarinics, so combining them is duplicate therapy. This increases anticholinergic effects such as dry mouth, urinary retention and glaucoma risk without added benefit.
Ce que signifie cette interaction, en termes simples
Aclidinium and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Duplicate long-acting muscarinic antagonism producing additive anticholinergic effects.
Conduite à tenir
Avoid concurrent use; keep only one LAMA-containing regimen.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Umeclidinium-vilanterol
Questions fréquentes
Can I take Aclidinium with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Aclidinium and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aclidinium and umeclidinium are both long-acting antimuscarinics, so combining them is duplicate therapy. This increases anticholinergic effects such as dry mouth, urinary retention and glaucoma risk without added benefit.
How serious is the interaction between Aclidinium and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; keep only one LAMA-containing regimen.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Amiodarone, Amitriptyline, Amoxapine. The full list is on the Umeclidinium-vilanterol page.
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