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Interactions médicamenteuses

Arformoterol + Umeclidinium-vilanterol

Gravité: Majeure

Arformoterol and Umeclidinium-vilanterol: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Both drugs are long-acting beta-2 agonists, so using them together duplicates therapy. This increases the risk of tachycardia, arrhythmia, tremor, hypokalemia and QT prolongation without added benefit.

Ce que signifie cette interaction, en termes simples

Arformoterol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Arformoterol belongs to Respiratory; Umeclidinium-vilanterol belongs to Respiratory.

Niveau de preuve: High

Pourquoi elle survient

Duplicate beta-2 agonist pharmacology with additive cardiovascular and metabolic effects.

Conduite à tenir

Avoid concurrent use of two long-acting beta-agonists and use only one. Monitor heart rate and potassium if a switch is under way.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Arformoterol with Umeclidinium-vilanterol?

MediHelp rates the interaction as major. Arformoterol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are long-acting beta-2 agonists, so using them together duplicates therapy. This increases the risk of tachycardia, arrhythmia, tremor, hypokalemia and QT prolongation without added benefit.

How serious is the interaction between Arformoterol and Umeclidinium-vilanterol?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta-agonists and use only one. Monitor heart rate and potassium if a switch is under way.

What other medicines interact with Umeclidinium-vilanterol?

MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.

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