Interactions médicamenteuses
Amoxapine + Umeclidinium-vilanterol
Gravité: Majeure
Amoxapine and Umeclidinium-vilanterol: major interaction.
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Résumé
Tricyclic antidepressants such as amoxapine can potentiate the cardiovascular effects of vilanterol, causing tachycardia and hypertension. Amoxapine may also prolong the QTc interval, adding to arrhythmia risk.
Ce que signifie cette interaction, en termes simples
Amoxapine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive adrenergic and QT-prolonging effects; reuptake inhibition potentiates beta-agonist actions.
Conduite à tenir
Avoid if possible or monitor heart rate, blood pressure and ECG closely. Correct electrolyte disturbances and consider alternative agents.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Umeclidinium-vilanterol
Questions fréquentes
Can I take Amoxapine with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Amoxapine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants such as amoxapine can potentiate the cardiovascular effects of vilanterol, causing tachycardia and hypertension. Amoxapine may also prolong the QTc interval, adding to arrhythmia risk.
How serious is the interaction between Amoxapine and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or monitor heart rate, blood pressure and ECG closely. Correct electrolyte disturbances and consider alternative agents.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
