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Interactions médicamenteuses

Carvedilol + Umeclidinium-vilanterol

Gravité: Majeure

Carvedilol and Umeclidinium-vilanterol: major interaction.

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Résumé

Carvedilol is a non-selective beta-blocker and can block the bronchodilating effect of vilanterol. It may provoke bronchospasm in patients with asthma or COPD.

Ce que signifie cette interaction, en termes simples

Carvedilol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Carvedilol belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.

Niveau de preuve: High

Pourquoi elle survient

Pharmacodynamic antagonism through beta-2 receptor blockade.

Conduite à tenir

Prefer a beta-1 selective blocker such as bisoprolol or metoprolol where a beta-blocker is needed. Monitor lung function and symptoms if carvedilol is continued.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Carvedilol with Umeclidinium-vilanterol?

MediHelp rates the interaction as major. Carvedilol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol is a non-selective beta-blocker and can block the bronchodilating effect of vilanterol. It may provoke bronchospasm in patients with asthma or COPD.

How serious is the interaction between Carvedilol and Umeclidinium-vilanterol?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a beta-1 selective blocker such as bisoprolol or metoprolol where a beta-blocker is needed. Monitor lung function and symptoms if carvedilol is continued.

What other medicines interact with Umeclidinium-vilanterol?

MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.

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