Interactions médicamenteuses
Adalimumab + Denosumab
Gravité: Modérée
Adalimumab and Denosumab: moderate interaction.
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Résumé
Both drugs have been linked to serious infections, and denosumab may contribute to infection risk, notably skin infections, in some patients. Combined with adalimumab's TNF blockade, vigilance for infection is warranted.
Ce que signifie cette interaction, en termes simples
Adalimumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Adalimumab belongs to Musculoskeletal; Denosumab belongs to Oncology.
Pourquoi elle survient
Possible additive infection risk; denosumab's RANKL inhibition may modestly affect immune signalling alongside TNF blockade.
Conduite à tenir
Monitor for signs of infection, especially skin and urinary infections, and treat early. Reassess denosumab if a serious infection occurs.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Adalimumab
- Adalimumab + Bcg vaccine live Contre-indiquée
- Adalimumab + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Adalimumab + Measles mumps and rubella vaccine Contre-indiquée
- Adalimumab + Measles mumps and rubella vaccine live Contre-indiquée
- Adalimumab + Measles mumps rubella and varicella vaccine live Contre-indiquée
- Adalimumab + Measles vaccine Contre-indiquée
Autres interactions de Denosumab
- Abatacept + Denosumab Modérée
- Alefacept + Denosumab Modérée
- Alemtuzumab + Denosumab Modérée
- Anakinra + Denosumab Modérée
- Azacitidine + Denosumab Modérée
- Azathioprine + Denosumab Modérée
Questions fréquentes
Can I take Adalimumab with Denosumab?
MediHelp rates the interaction as moderate. Adalimumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to serious infections, and denosumab may contribute to infection risk, notably skin infections, in some patients. Combined with adalimumab's TNF blockade, vigilance for infection is warranted.
How serious is the interaction between Adalimumab and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection, especially skin and urinary infections, and treat early. Reassess denosumab if a serious infection occurs.
What other medicines interact with Adalimumab?
MediHelp also lists interactions of Adalimumab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Adalimumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
