Interactions médicamenteuses
Alemtuzumab + Denosumab
Gravité: Modérée
Alemtuzumab and Denosumab: moderate interaction.
Dernière mise à jour
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Résumé
Alemtuzumab causes profound, prolonged lymphocyte depletion, and denosumab has been linked to serious infections. The combination may increase the risk of serious or opportunistic infection.
Ce que signifie cette interaction, en termes simples
Alemtuzumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alemtuzumab belongs to Miscellaneous; Denosumab belongs to Oncology.
Pourquoi elle survient
Additive immunosuppression from profound lymphocyte depletion by alemtuzumab and RANKL inhibition by denosumab.
Conduite à tenir
Monitor closely for infection during and after alemtuzumab, and consider whether denosumab can be timed or deferred. Start prompt evaluation of any fever or infectious symptoms.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Denosumab
- Abatacept + Denosumab Modérée
- Adalimumab + Denosumab Modérée
- Alefacept + Denosumab Modérée
- Anakinra + Denosumab Modérée
- Azacitidine + Denosumab Modérée
- Azathioprine + Denosumab Modérée
Autres interactions de Alemtuzumab
- Alemtuzumab + Fingolimod Majeure
- Alemtuzumab + Ifosfamide Majeure
- Alemtuzumab + Lomustine Majeure
- Alemtuzumab + Ozanimod Majeure
- Alemtuzumab + Siponimod Majeure
- Alemtuzumab + Upadacitinib Majeure
Questions fréquentes
Can I take Alemtuzumab with Denosumab?
MediHelp rates the interaction as moderate. Alemtuzumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alemtuzumab causes profound, prolonged lymphocyte depletion, and denosumab has been linked to serious infections. The combination may increase the risk of serious or opportunistic infection.
How serious is the interaction between Alemtuzumab and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for infection during and after alemtuzumab, and consider whether denosumab can be timed or deferred. Start prompt evaluation of any fever or infectious symptoms.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
