Interactions médicamenteuses
Alefacept + Denosumab
Gravité: Modérée
Alefacept and Denosumab: moderate interaction.
Dernière mise à jour
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Résumé
Denosumab is associated with a higher rate of serious infections, and alefacept suppresses T-cell function. Used together they may further raise infection risk in an already immunocompromised patient.
Ce que signifie cette interaction, en termes simples
Alefacept and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Additive immunosuppression; denosumab inhibits RANKL signaling affecting immune cells while alefacept reduces CD4+ and CD8+ T-cell counts.
Conduite à tenir
Monitor for signs of infection and evaluate the need for ongoing denosumab in patients on immunosuppressants. Treat infections promptly.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Denosumab
- Abatacept + Denosumab Modérée
- Adalimumab + Denosumab Modérée
- Alemtuzumab + Denosumab Modérée
- Anakinra + Denosumab Modérée
- Azacitidine + Denosumab Modérée
- Azathioprine + Denosumab Modérée
Questions fréquentes
Can I take Alefacept with Denosumab?
MediHelp rates the interaction as moderate. Alefacept and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab is associated with a higher rate of serious infections, and alefacept suppresses T-cell function. Used together they may further raise infection risk in an already immunocompromised patient.
How serious is the interaction between Alefacept and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and evaluate the need for ongoing denosumab in patients on immunosuppressants. Treat infections promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alemtuzumab. The full list is on the Denosumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
