Interactions médicamenteuses
Azacitidine + Denosumab
Gravité: Modérée
Azacitidine and Denosumab: moderate interaction.
Dernière mise à jour
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Résumé
Denosumab labeling warns of serious infections, including skin infections, in patients with impaired immunity. Azacitidine causes myelosuppression and neutropenia, which adds to infection risk.
Ce que signifie cette interaction, en termes simples
Azacitidine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Denosumab belongs to Oncology.
Pourquoi elle survient
Additive infection risk: denosumab alters RANKL-mediated immune signalling, while azacitidine suppresses bone marrow function.
Conduite à tenir
Monitor for signs of infection and check blood counts regularly. Treat infections promptly and reassess the need for denosumab if serious infections develop.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Denosumab
- Abatacept + Denosumab Modérée
- Adalimumab + Denosumab Modérée
- Alefacept + Denosumab Modérée
- Alemtuzumab + Denosumab Modérée
- Anakinra + Denosumab Modérée
- Azathioprine + Denosumab Modérée
Autres interactions de Azacitidine
- Azacitidine + Fingolimod Majeure
- Azacitidine + Siponimod Majeure
- Azacitidine + Dichlorphenamide Modérée
- Azacitidine + Hydroxyurea Modérée
- Azacitidine + Trastuzumab Modérée
Questions fréquentes
Can I take Azacitidine with Denosumab?
MediHelp rates the interaction as moderate. Azacitidine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab labeling warns of serious infections, including skin infections, in patients with impaired immunity. Azacitidine causes myelosuppression and neutropenia, which adds to infection risk.
How serious is the interaction between Azacitidine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts regularly. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
