Interactions médicamenteuses
Adenovirus types 4 and 7 live + Mitoxantrone
Gravité: Contre-indiquée
Adenovirus types 4 and 7 live and Mitoxantrone: contraindicated interaction.
Dernière mise à jour
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Résumé
Mitoxantrone causes myelosuppression and immunosuppression. A live oral adenovirus vaccine could cause disseminated vaccine-virus infection, and the immune response to it will be poor.
Ce que signifie cette interaction, en termes simples
Adenovirus types 4 and 7 live and Mitoxantrone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
Conduite à tenir
Do not give live vaccines during mitoxantrone therapy. Wait at least 3 months after stopping and confirm immune recovery before vaccinating.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Mitoxantrone
Questions fréquentes
Can I take Adenovirus types 4 and 7 live with Mitoxantrone?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Mitoxantrone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mitoxantrone causes myelosuppression and immunosuppression. A live oral adenovirus vaccine could cause disseminated vaccine-virus infection, and the immune response to it will be poor.
How serious is the interaction between Adenovirus types 4 and 7 live and Mitoxantrone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during mitoxantrone therapy. Wait at least 3 months after stopping and confirm immune recovery before vaccinating.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Axicabtagene ciloleucel, Belatacept, Brexucabtagene autoleucel. The full list is on the Mitoxantrone page.
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