Interactions médicamenteuses
Cyclosporine + Mitoxantrone
Gravité: Majeure
Cyclosporine and Mitoxantrone: major interaction.
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Résumé
Cyclosporine can increase mitoxantrone exposure, potentially intensifying myelosuppression and cardiotoxicity. Additive immunosuppression also raises infection risk.
Ce que signifie cette interaction, en termes simples
Cyclosporine and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Inhibition of P-glycoprotein and BCRP efflux by cyclosporine reduces mitoxantrone clearance, with additive immunosuppression.
Conduite à tenir
Monitor blood counts and cardiac function closely, and consider reducing the mitoxantrone dose.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Mitoxantrone
- Adenovirus types 4 and 7 live + Mitoxantrone Contre-indiquée
- Axicabtagene ciloleucel + Mitoxantrone Majeure
- Belatacept + Mitoxantrone Majeure
- Brexucabtagene autoleucel + Mitoxantrone Majeure
- Ciltacabtagene autoleucel + Mitoxantrone Majeure
- Deferiprone + Mitoxantrone Majeure
Questions fréquentes
Can I take Cyclosporine with Mitoxantrone?
MediHelp rates the interaction as major. Cyclosporine and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can increase mitoxantrone exposure, potentially intensifying myelosuppression and cardiotoxicity. Additive immunosuppression also raises infection risk.
How serious is the interaction between Cyclosporine and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely, and consider reducing the mitoxantrone dose.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
