Interactions médicamenteuses
Deferiprone + Mitoxantrone
Gravité: Majeure
Deferiprone and Mitoxantrone: major interaction.
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Résumé
Both drugs can cause neutropenia, and deferiprone can cause agranulocytosis. Together they increase the risk of severe neutropenia and serious infection.
Ce que signifie cette interaction, en termes simples
Deferiprone and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Mitoxantrone belongs to Central Nervous System.
Pourquoi elle survient
Additive bone marrow suppression.
Conduite à tenir
Avoid if an alternative exists; otherwise monitor absolute neutrophil count more often and interrupt deferiprone if neutropenia develops.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Mitoxantrone
- Adenovirus types 4 and 7 live + Mitoxantrone Contre-indiquée
- Axicabtagene ciloleucel + Mitoxantrone Majeure
- Belatacept + Mitoxantrone Majeure
- Brexucabtagene autoleucel + Mitoxantrone Majeure
- Ciltacabtagene autoleucel + Mitoxantrone Majeure
- Cyclosporine + Mitoxantrone Majeure
Autres interactions de Deferiprone
- Clozapine + Deferiprone Contre-indiquée
- Abemaciclib + Deferiprone Majeure
- Acalabrutinib + Deferiprone Majeure
- Ado-trastuzumab emtansine + Deferiprone Majeure
- Ado-trastuzumab + Deferiprone Majeure
- Aldesleukin + Deferiprone Majeure
Questions fréquentes
Can I take Deferiprone with Mitoxantrone?
MediHelp rates the interaction as major. Deferiprone and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause neutropenia, and deferiprone can cause agranulocytosis. Together they increase the risk of severe neutropenia and serious infection.
How serious is the interaction between Deferiprone and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists; otherwise monitor absolute neutrophil count more often and interrupt deferiprone if neutropenia develops.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
