Référentiel des médicaments
Mitoxantrone
Mitoxantrone is a medicine in the class central nervous system. It is used for leukemia.
- Classe médicamenteuse: Central Nervous System
- Indications: leukemia
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Formes courantes
- injection, solution
- Dosages courants
- 20 mg, 2 mg, 20 mg/10 ml
- Interactions connues
- 59 (Contre-indiquée: 1 · Majeure: 20 · Modérée: 31 · Mineure: 7)
- Noms commerciaux
- 5
- Pays et marchés
- 3
Indications
Mécanisme d'action
Anthracenedione; DNA-reactive agent with cell cycle nonspecific cytocidal activity that intercalates into DNA resulting in cross-links and strand breaks; inhibits DNA and RNA synthesis
Posologie adulte habituelle (résumé de la notice)
Secondary Progressive Multiple Sclerosis: 12 mg/m² short IV (5-15 minutes) infusion q3Months, Not to exceed lifetime cumulative dose of 140 mg/m²
Grossesse et allaitement
- Grossesse
- Unsafe Cytotoxic; can harm the fetus. Women with multiple sclerosis need a negative pregnancy test before each dose and effective contraception. Avoid in pregnancy, especially the 1st trimester; cancer treatment later in pregnancy is a specialist decision.
- Allaitement
- Unsafe Passes into milk and was still found 28 days after a dose. US label: stop breastfeeding before starting treatment. LactMed: breastfeeding is considered contraindicated during antineoplastic therapy.
Effets indésirables signalés
- Upper respiratory tract infection
- Diarrhea
- Nausea
- Alopecia
- Urinary tract infection
- Amenorrhea
Précautions particulières
- Not indicated for primary progressive MS
- Avoid pregnancy
- Risk of cardiotoxicity & secondary AML
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (59)
- Adenovirus types 4 and 7 live + Mitoxantrone Contraindicated
- Axicabtagene ciloleucel + Mitoxantrone Major
- Belatacept + Mitoxantrone Major
- Brexucabtagene autoleucel + Mitoxantrone Major
- Ciltacabtagene autoleucel + Mitoxantrone Major
- Cyclosporine + Mitoxantrone Major
- Deferiprone + Mitoxantrone Major
- Etrasimod + Mitoxantrone Major
- Fingolimod + Mitoxantrone Major
- Hydroxyurea + Mitoxantrone Major
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Mitoxantrone used for?
Mitoxantrone is a medicine in the class central nervous system. It is used for Leukemia, Multiple sclerosis, Prostate cancer.
What side effects have been reported with Mitoxantrone?
Upper respiratory tract infection, Diarrhea, Nausea, Alopecia, Urinary tract infection, Amenorrhea.
Can Mitoxantrone be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Cytotoxic; can harm the fetus. Women with multiple sclerosis need a negative pregnancy test before each dose and effective contraception. Avoid in pregnancy, especially the 1st trimester; cancer treatment later in pregnancy is a specialist decision. Breastfeeding: Unsafe. Passes into milk and was still found 28 days after a dose. US label: stop breastfeeding before starting treatment. LactMed: breastfeeding is considered contraindicated during antineoplastic therapy.
What does Mitoxantrone interact with?
MediHelp lists 59 known interactions for Mitoxantrone. Contraindicated: 1 · Major: 20 · Moderate: 31 · Minor: 7. The most serious include Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept.
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