Interactions médicamenteuses
Alfentanil + Diphenoxylate-atropine
Gravité: Majeure
Alfentanil and Diphenoxylate-atropine: major interaction.
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Résumé
Diphenoxylate is an opioid, and together with alfentanil it can increase sedation and respiratory depression. Risk is higher at high diphenoxylate doses or in children and those with hepatic impairment.
Ce que signifie cette interaction, en termes simples
Alfentanil and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive opioid-mediated CNS and respiratory depression.
Conduite à tenir
Monitor respiratory rate and sedation level during alfentanil use and reduce the alfentanil dose as needed. Hold diphenoxylate-atropine where possible around procedures.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contre-indiquée
- Diphenoxylate-atropine + Phenelzine Contre-indiquée
- Diphenoxylate-atropine + Tranylcypromine Contre-indiquée
- Alvimopan + Diphenoxylate-atropine Majeure
- Amitriptyline + Diphenoxylate-atropine Majeure
- Amobarbital + Diphenoxylate-atropine Majeure
Questions fréquentes
Can I take Alfentanil with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Alfentanil and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diphenoxylate is an opioid, and together with alfentanil it can increase sedation and respiratory depression. Risk is higher at high diphenoxylate doses or in children and those with hepatic impairment.
How serious is the interaction between Alfentanil and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation level during alfentanil use and reduce the alfentanil dose as needed. Hold diphenoxylate-atropine where possible around procedures.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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