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Interactions médicamenteuses

Diphenoxylate-atropine + Tranylcypromine

Gravité: Contre-indiquée

Diphenoxylate-atropine and Tranylcypromine: contraindicated interaction.

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Résumé

Diphenoxylate is labeled as potentially causing hypertensive crisis when given with MAO inhibitors. Tranylcypromine is a nonselective irreversible MAOI, so the risk of severe hypertension and agitation is substantial.

Ce que signifie cette interaction, en termes simples

Diphenoxylate-atropine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Diphenoxylate-atropine belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Irreversible MAO inhibition may potentiate the pressor and CNS effects of the opioid; the exact mechanism is not fully defined.

Conduite à tenir

Do not co-administer, and do not start diphenoxylate-atropine within 14 days of stopping tranylcypromine. Use a different antidiarrheal such as loperamide.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Diphenoxylate-atropine with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Diphenoxylate-atropine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diphenoxylate is labeled as potentially causing hypertensive crisis when given with MAO inhibitors. Tranylcypromine is a nonselective irreversible MAOI, so the risk of severe hypertension and agitation is substantial.

How serious is the interaction between Diphenoxylate-atropine and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and do not start diphenoxylate-atropine within 14 days of stopping tranylcypromine. Use a different antidiarrheal such as loperamide.

What other medicines interact with Diphenoxylate-atropine?

MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Alfentanil. The full list is on the Diphenoxylate-atropine page.

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