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Interactions médicamenteuses

Diphenoxylate-atropine + Phenelzine

Gravité: Contre-indiquée

Diphenoxylate-atropine and Phenelzine: contraindicated interaction.

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Résumé

Diphenoxylate is structurally similar to meperidine, and combining with MAO inhibitors may provoke hypertensive crisis, hyperpyrexia, hypotension or CNS depression. Labeling warns against concurrent use. Reactions could be severe or fatal.

Ce que signifie cette interaction, en termes simples

Diphenoxylate-atropine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Diphenoxylate-atropine belongs to Gastrointestinal Tract; Phenelzine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition may potentiate diphenoxylate through a meperidine-like interaction; the exact mechanism is not fully established.

Conduite à tenir

Do not combine, and allow 14 days after stopping phenelzine before using diphenoxylate-atropine. Choose a non-opioid antidiarrheal alternative.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Diphenoxylate-atropine with Phenelzine?

MediHelp rates the interaction as contraindicated. Diphenoxylate-atropine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diphenoxylate is structurally similar to meperidine, and combining with MAO inhibitors may provoke hypertensive crisis, hyperpyrexia, hypotension or CNS depression. Labeling warns against concurrent use. Reactions could be severe or fatal.

How serious is the interaction between Diphenoxylate-atropine and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine, and allow 14 days after stopping phenelzine before using diphenoxylate-atropine. Choose a non-opioid antidiarrheal alternative.

What other medicines interact with Diphenoxylate-atropine?

MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Tranylcypromine, Alfentanil. The full list is on the Diphenoxylate-atropine page.

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