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Interactions médicamenteuses

Diphenoxylate-atropine + Isocarboxazid

Gravité: Contre-indiquée

Diphenoxylate-atropine and Isocarboxazid: contraindicated interaction.

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Résumé

Diphenoxylate is structurally related to meperidine, and MAO inhibitors can cause severe reactions with such opioids. Hypertensive crisis, hyperpyrexia, hypotension, somnolence or death may occur. Labeling advises against use of diphenoxylate with MAO inhibitors.

Ce que signifie cette interaction, en termes simples

Diphenoxylate-atropine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Diphenoxylate-atropine belongs to Gastrointestinal Tract; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition may potentiate diphenoxylate through a meperidine-like interaction; the exact mechanism is not fully established.

Conduite à tenir

Do not use together or within 14 days of stopping the MAO inhibitor. Use a non-opioid antidiarrheal alternative.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Diphenoxylate-atropine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Diphenoxylate-atropine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diphenoxylate is structurally related to meperidine, and MAO inhibitors can cause severe reactions with such opioids. Hypertensive crisis, hyperpyrexia, hypotension, somnolence or death may occur. Labeling advises against use of diphenoxylate with MAO inhibitors.

How serious is the interaction between Diphenoxylate-atropine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAO inhibitor. Use a non-opioid antidiarrheal alternative.

What other medicines interact with Diphenoxylate-atropine?

MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Phenelzine, Tranylcypromine, Alfentanil. The full list is on the Diphenoxylate-atropine page.

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