Interactions médicamenteuses
Amlodipine-perindopril + Sacubitril / valsartan
Gravité: Contre-indiquée
Amlodipine-perindopril and Sacubitril / valsartan: contraindicated interaction.
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Résumé
Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
Ce que signifie cette interaction, en termes simples
Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Additive RAAS blockade, and neprilysin inhibition combined with ACE inhibition both impair bradykinin breakdown, raising angioedema risk.
Conduite à tenir
Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contre-indiquée
- Amlodipine-perindopril + Protein a column Contre-indiquée
- Amifostine + Amlodipine-perindopril Majeure
- Amiloride + Amlodipine-perindopril Majeure
- Amlodipine-perindopril + Azilsartan Majeure
- Amlodipine-perindopril + Candesartan Majeure
Questions fréquentes
Can I take Amlodipine-perindopril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
How serious is the interaction between Amlodipine-perindopril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Amifostine. The full list is on the Amlodipine-perindopril page.
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